Set in the future, the plot follows Zouichi Kanoe and his AI companion Fuyu Kanoe, whose luminous form is integrated into the system of his motorcycle. They are agents sent by Toha Heavy Industries to retrieve humans with the ability to resist and transmute the N5S infection, which is spreading across the world, turning humans into “Drones”; disfigured, zombie-like beings.
Biomega is the second prequel to BLAME! and is the story of how the world in BLAME! became shrouded by the Megastructure.
Biomega was originally serialized in Weekly Young Magazine from June 14 to September 6, 2004 (2004 #29~#41) but went on hiatus thereafter. Serialization resumed 2 years later in Ultra Jump on May 18, 2006 (2006-06).
The series was published in English by VIZ Media under the VIZ Signature imprint from February 2, 2010 to May 17, 2011 and in Italian by Panini Comics under the Planet Manga imprint from December 6, 2007 to September 13, 2009, which was re-released in a 2-in-1 omnibus edition from April 30, 2014 to July 26, 2014.